Until recently, cardiotoxicity in the setting of a malignant disease was attributed solely to the detrimental effects of chemo‐ and/or radio‐therapy to the heart. On this account, the focus was on the evaluation of well‐established cardiac biomarkers for the early detection of myocardial damage. Currently, this view has been revised. Cardiotoxicity is not restricted to a single organ but instead affects the endothelium as a whole. Indeed, it has come into light that not only cancer therapy but also malignant cells (...) per se can impair the cardiovascular system, through a paracrine and endocrine mode of action. Even more intriguingly, a clear interplay between molecular pathways involved in cancer and cardiovascular disease has become prevalent, suggesting a common nominator that governs the pathophysiology of these two entities. Taken together, our strategy in the quest of novel biomarkers in the emerging field of cardio‐oncology should be critically reshaped. (shrink)

Graphical AbstractWith DNA damage being a primary anti-cancertarget, a need has arisen for the development of an approach that is a harmlessfor normal tissues but allows for cancer cell-specific cytotoxicity. Previous researchfrom K. Gurova's suggests that small compounds, namely curaxins that bind theDNA can cause chromatin instability and cell death in a cancer cell-specificmanner. In this brief perspective commentary, we investigate how the scientificcommunity has further developed this anti-cancer approach.

The present study investigates the way infants express their emotions in relation to parental feelings between maternal and paternal questions and direct requests. We therefore compared interpersonal engagement accompanying parental questions and direct requests between infant–mother and infant–father interactions. We video-recorded spontaneous communication between 11 infant–mother and 11 infant–father dyads—from the 2nd to the 6th month—in their home. The main results of this study are summarized as follows: (a) there aresimilaritiesin the way preverbal infants use their affections in spontaneous interactions (...) with their mothers and fathers to express signs of sensitivity in sharing knowledge through questions and direct requests; and (b) the developmental trajectories of face-to-face emotional coordination in the course of parental questions descend in a similar way for both parents across the age range of this study. Regarding the developmental trajectories of emotional non-coordination, there is evidence of a linear trend in terms of age difference between the parents’ gender with fathers showing the steeper slope. The results are discussed in relation to the theory of intersubjectivity. (shrink)

Activating Transcription Factor-2 is a sequence-specific DNA-binding protein that belongs to the bZIP family of proteins and plays diverse roles in the mammalian cells. In response to stress stimuli, it activates a variety of gene targets including cyclin A, cyclin D and c-jun, which are involved in oncogenesis in various tissue types. ATF-2 expression has been correlated with maintenance of a cancer cell phenotype. However, other studies demonstrate an antiproliferative or apoptotic role for ATF-2. In this review, we summarize the (...) signaling pathways that activate ATF-2, as well as its downstream targets. We examine the role of ATF-2 in carcinogenesis with respect to other bZIP proteins, using data from studies in human cancer cell lines, human tumours and mouse models, and we propose a potential model for its function in carcinogenesis, as well as a theoretical basis for its utility in anticancer drug design. (shrink)

BackgroundThe Asclepion of Epidaurus is one of the first healing environments in the world. Descendants of Asclepius, specifically medical students, have been singularly deprived of any information concerning this legacy. This article illuminates the role of Asclepion of Epidaurus and examines the view of medical students upon the subject and the possible benefits of this knowledge in their medical education.MethodsThe participants were 105 senior-year students from the Athens Medical School, who attended a multi-media assisted lecture related to the structure and (...) the role of the Asclepion of Epidaurus. Afterwards, they answered anonymously a questionnaire of 12 pairs of opposite adjectives in order to describe their view regarding the meaning of Asclepion. The method used in the evaluation of their answers was that of semantic differential.ResultsThe attitude of the students towards the meaning of Asclepion was positive, showing interest and excitement about a powerful, though unfamiliar piece of knowledge.ConclusionToday’s novice doctors have welcomed the concept of Asclepion as essential knowledge for the service they will be called to fulfill. The potential benefits of the Asclepian ideals in medical education and ethos are thoroughly discussed. (shrink)

This book examines the metaphysical issues regarding the powerful qualities view in all its various forms. The author also develops and defends his own version of the powerful qualities view, which he calls powerful categoricalism. In recent years, the powerful qualities view about the nature of properties has received considerable attention in the philosophical literature. The core tenet of the powerful qualities view is that properties are both dispositional and categorical/qualitative. Despite the increased popularity of the powerful qualities view, there (...) is no book-length presentation of the view in its distinct versions. The first part of this book analyzes the advantages and drawbacks of each version of the theory paying special attention to those difficulties that make it unstable and perhaps incomprehensible. In the second part, the author shows how a developed version of a dualist model for the origin of natural modality-according to which the specific behaviour of things in the world is the outcome of both the thin power properties have to be nomically relatable and certain nomic relations that determine properties' nomological role-can support an alternative understanding of the main tenet of the powerful qualities view. This part, in combination with the discussion of the difficulties of the other versions, not only defends the tenability of powerful categoricalism but also its superiority over the other extant versions. The Metaphysics of Powerful Qualities makes an original contribution to an ongoing debate in contemporary metaphysics. (shrink)

Main figures in Byzantium after the Byzantium were Ioannis Zygomalas (1498-1584) and his son and fellow Theodosius (1544-1607) who drew a spiritual path that left many and rich traces and presumptions. They served in the Patriarchate of Constantinople in key positions. There they taught the ancient Greek language and they copied and distributed manuscripts of works of ancient and byzantine writers. Their mailing correspondence with European scholars and travelers is well known. Thanks to that, the humanistic Europe met not only (...) the Greek scholars of the 16th c. but also their spoken language of that era, as a continuation of the Greek classical times and the Byzantine world. The historical information concerning them that has been saved is of interest to many categories of specialists of human sciences: Theology and Philosophy, Social History, History of Law and Institutions, Literature and Linguistics, Palaeography and Codicology, Letter-writing. Authors: Hans Eideneier, Ernst Gamillscheg, Christian Gastgeber, Andreas Rhoby, Dora E. Solti, D. G. Apostolopoulos, Athanasios E. Karathanasis, Vassilis Katsaros, R. Georgios D. Metallinos, Machi Paizi-Apostolopoulou, Stavros Perentidis, Konstantinos Pitsakis, Georgios Steiris, Notis Toufexis, Andronikos Falaggas. (shrink)

Self–other discrimination was investigated with point-light displays in which actions were presented with or without additional auditory information. Participants first executed different actions in time with music. In two subsequent experiments, they watched point-light displays of their own or another participant’s recorded actions, and were asked to identify the agent . Manipulations were applied to the visual information and to the auditory information . Results indicate that self-recognition was better than chance in all conditions and was highest when observing relatively (...) unconstrained patterns of movement. Auditory information did not increase accuracy even with the most ambiguous visual displays, suggesting that judgments of agent identity depend much more on motor cues than on auditory or audiovisual information. (shrink)

Given the contemporary ambivalent standpoints toward the future of artificial intelligence, recently denoted as the phenomenon of Singularitarianism, Gregory Bateson’s core theories of ecology of mind, schismogenesis, and double bind, are hereby revisited, taken out of their respective sociological, anthropological, and psychotherapeutic contexts and recontextualized in the field of Roboethics as to a twofold aim: the proposal of a rigid ethical standpoint toward both artificial and non-artificial agents, and an explanatory analysis of the reasons bringing about such a polarized outcome (...) of contradictory views in regard to the future of robots. Firstly, the paper applies the Batesonian ecology of mind for constructing a unified roboethical framework which endorses a flat ontology embracing multiple forms of agency, borrowing elements from Floridi’s information ethics, classic virtue ethics, Felix Guattari’s ecosophy, Braidotti’s posthumanism, and the Japanese animist doctrine of Rinri. The proposed framework wishes to act as a pragmatic solution to the endless dispute regarding the nature of consciousness or the natural/artificial dichotomy and as a further argumentation against the recognition of future artificial agency as a potential existential threat. Secondly, schismogenic analysis is employed to describe the emergence of the hostile human–robot cultural contact, tracing its origins in the early scientific discourse of man–machine symbiosis up to the contemporary countermeasures against superintelligent agents. Thirdly, Bateson’s double bind theory is utilized as an analytic methodological tool of humanity’s collective agency, leading to the hypothesis of collective schizophrenic symptomatology, due to the constancy and intensity of confronting messages emitted by either proponents or opponents of artificial intelligence. The double bind’s treatment is the mirroring “therapeutic double bind,” and the article concludes in proposing the conceptual pragmatic imperative necessary for such a condition to follow: humanity’s conscience of habitualizing danger and familiarization with its possible future extinction, as the result of a progressive blurrification between natural and artificial agency, succeeded by a totally non-organic intelligent form of agency. (shrink)

This book explores the dispositional and categorical debates on the metaphysics of properties. It defends the view that all fundamental properties and relations are contingently categorical, while also examining alternative accounts of the nature of properties. Drawing upon both established research and the author's own investigation into the broader discipline of the metaphysics of science, this book provides a comprehensive study of the many views and opinions regarding a most debatable topic in contemporary metaphysics.

Conducting marine mammal research can raise several important ethical issues. For example, the continuation of whaling for commercial purposes despite the international moratorium provides opportunities for scientists to obtain data and tissue samples. In 2021 we analysed 35 peer-reviewed papers reporting research based on collaborations with Icelandic whalers. Results highlighted little consideration or understanding of the legal and ethical issues associated with the deliberate killing of whales amongst those researchers, funding bodies, universities and journals involved. Ethical statements were rarely provided. (...) Those that were written were incomplete. Whilst research using whaling data may seem acceptable to some, it often becomes hard to justify when subject to scrutiny by the media and the public. Thus, there is a particular danger of reputational harm for early career researchers who may become unwittingly involved in such activities. Here we also consider the broader variety of ethical issues raised by non-lethal research (both historical and recent) on marine mammals including tagging and biopsy. We discuss instances where study animals were harmed or even killed and where the public mistook tags for harpoons. Without clear guidelines, reviewers and journal editors are put in an impossible position when considering whether to reject papers on ethical grounds. We propose that for such studies, universities, funders, journals, and permit issuers must require ethical assessments and that journals more effectively implement their existing policies on publishing ethical statements. The professional marine mammal societies need to work together to produce modern ethical guidance. Such guidance should require transparency in the provenance of data and samples while including advice on law, welfare issues, involvement of local scientists, and offshoring. Furthermore, it should require appraisal of and justification for the absolute necessity of invasive procedures. As is already the case in biomedical disciplines, ethical statements should be required in marine mammal science. (shrink)

“For there shall be days when you will say: Blessed is the womb which has not conceived, and those breasts which have not given suck.”The Apocryphal Gospel of Thomas (1)“ Oh man! why is the world becoming so narrow for you? You want to possess it alone; but if you had possessed it, it would not have been spacious enough for you:Ah! this is the pride of the devil who has fallen from heaven into hell.”.

Categorical Monism (that is, the view that all fundamental natural properties are purely categorical) has recently been challenged by a number of philosophers. In this paper, I examine a challenge which can be based on Gabriele Contessa’s [10] defence of the view that only powers can confer dispositions. In his paper Contessa argues against what he calls the Nomic Theory of Disposition Conferral (NTDC). According to NTDC, in each world in which they exist, (categorical) properties confer specific dispositions on their (...) bearers; yet, which disposition a (categorical) property confers on its bearers depends on what the (contingent) laws of nature happen to be. Contessa, inter alia, rests his case on an intuitive analogy between cases of mimicking (in which objects do not actually possess the dispositions associated with their displayed behaviour) and cases of disposition conferral through the action of laws. In this paper, I criticize various aspects of Contessa’s argumentation and show that the conclusion he arrives at (that is, only powers can confer dispositions) is controversial. (shrink)

Dans la littérature ascétique, orgueil et humilité sont considérés comme la matrice, respectivement, de tous les vices et de toutes les vertus. En outre, travailler sur les autres vertus ainsi que sur l’humilité elle-même risque de nourrir l’orgueil. Le présent article confronte ces perspectives avec des recherches récentes en psychologie du comportement moral et de la personnalité qui ont investigué sur le narcissisme, l’estime de soi, la modestie et l’humilité. Il poursuit un triple objectif. Primo, examiner la pertinence des conceptions (...) de la littérature ascétique sur le caractère pluridimensionnel de l’orgueil et de l’humilité: rapport à soi, aux autres, et à Dieu. Secundo, examiner si la valorisation religieuse de l’humilité se traduit effectivement dans les attitudes et comportements des croyants par une modestie et une humilité plus grande. Tertio, proposer des pistes qui permettent d’envisager sereinement le combat spirituel contre l’orgueil de manière à éviter les vicissitudes qui lui sont inhérentes ou associées: narcissisme caché, déresponsabilisation, culpabilisme excessif, fausse humilité et compensation par un altruisme égoïste. (shrink)

The authors are focusing on the relation of migration and labour by discussing Michael Hardt and Antonio Negri’s « Empire » on the one hand, and Giorgio Agamben’s notion of Lager on the other. Migration, they argue, can be understood as a form of class struggle, in which demands for autonomy and self-determination find their spontaneous expression.

Most metaphysicians agree that powers can exist without being manifested. The main goal of this paper is to show that adherents of an unrestricted version of Dispositional Monism cannot provide a plausible metaphysical account of the difference between a situation in which a power-instance is not manifested and a situation in which a manifestation of that power-instance actually occurs unless they undermine their own view. To this end, two kinds of manifestation-relation are introduced and it is argued that dispositional monists (...) should appeal to the former in order to offer the required account. After defending the introduction of token-level-manifestation-relations against objections to their metaphysical robustness and explanatory non-redundancy, it is finally argued that their existence is incompatible with the core tenet of an unrestricted form of Dispositional Monism because they cannot be powers. (shrink)

My discussion will concern itself with mathematics, medicine and the possible relations between the two. It will be an exercise in logical analysis, a review of some sad, sad facts, and in some sense a promise of glad tidings. In short, it will be an effort to bring the immortal inhabitants of the mathematical heaven into harmonious relations with the mortal ills of man's vale of tears.As to the curious role of mathematics with respect to the natural sciences, several preliminary (...) observations insist on prompt consideration. It is a matter of common knowledge, for example, that mathematics is being constantly applied to physics. With great success, Galileo wedded the two in his study of motion down an inclined plane. The mathematics he used to describe the physical phenomenon involved the equation of a parabola. His daring genius thus got far beyond the conventional circles that were permitted to motion by theology. His courageous use of the then “higher mathematics” was followed by centuries of application of still higher and higher mathematics, till now a small army of mathematicians is busy almost exclusively with the problem of inventing or discovering new varieties of mathematics which could serve physics better and better. The mathematical physicist of to-day is a specialist, nine-tenths mathematician, one-tenth physicist, with the nine-tenths serving the one-tenth. (shrink)

Until recently, the powerful qualities view about properties has been effectively identified with the so-called identity theory. Yet, the difficulties that the latter faces (especially concerning the interpretation of its core claim that dispositionality and qualitativity are identical) have led some metaphysicians to propose (at least provisionally) new versions of the powerful qualities view. This paper discusses the prospects of three such versions: the compound view, the higher-order properties theory and the dual aspect account. It is argued that the compound (...) view is in fact property dualism in disguise, while the higher-order properties theory does not by itself provide a metaphysically convincing solution to Armstrong’s dilemma concerning the modal status of the relation between dispositionality and categoricality. Finally, it is argued that it is not clear whether the dual aspect account is distinct from identity theory and pure powerism. (shrink)

Most recently Smart and Thébault revived an almost forgotten debate between Katzav and Ellis on the compatibility of Hamilton’s Principle with Dispositional Essentialism. Katzav’s arguments inter alia aim to show that HP presupposes a kind of metaphysical contingency which is at odds with the basic tenets of DE, and offers explanations of a different type and direction from those given by DE. In this paper I argue that though dispositional essentialists might adequately respond to these arguments, the question about the (...) compatibility of HP with DE has not been answered yet; therefore, dispositional essentialists have not yet provided an illuminating DE-friendly metaphysical account of HP. (shrink)

In the last part of the Timaeus, where Plato presents his ideas about human physiology but also about biology in general, we find the combined activity of Intellect and Necessity. In this essay I investigate whether Plato, apart from his general statement about the combined activity of Reason and Necessity, proposes a more specific method of biological research. For this purpose I am going to examine some methodological passages as well as the way in which he exposes and develops his (...) views about the human body and its organs. (shrink)

A number of metaphysicians and philosophers of science have raised the issue of themodalityof the fundamental structures of the world. Although the debate so far has been largely focused on the (alleged) inherent causal character of fundamental structures, one aspect of it has naturally taken its place as part of the dispositional/categorical debate. In this paper, I focus on the latter in the case of the fundamentalsymmetrystructures. After putting forward the necessary metaphysical presuppositions for the debate to make sense, I (...) offer an argument which undermines the plausibility of a dispositionalist account of fundamental symmetry structures. (shrink)

Previous research on religion and helping has left some questions unanswered. In the present study, participants expressed willingness to help groups of people in need, and this after having been religiously versus non-religiously stimulated. The activation of religious context increased the willingness to help, but only the homeless. Orthodox religious people tended to consider the targets responsible for their problem, an association partially mediated by the belief in a just world for other. Symbolic thinking was associated with willingness for helping, (...) an association partially mediated by the belief in ultimate justice. Results suggest a limited and conditional prosociality as a consequence of religion. (shrink)

The bulk of the literature concerning the governing role of non-Humean laws has been concentrated on the alleged incapability of higher order nomic facts to determine the regularities in the behaviour of actual objects, the so-called Inference Problem. Most recently Ioannidis, Livanios and Psillos (2021) argue that an adequate solution to the Inference Problem requires an answer to the question of how nomic relations manage to ‘tell’ properties what to do. Ioannidis et al. dub the difficulty that all extant accounts (...) of governing laws face to give such an answer, the Governing Problem and introduce a Dualist Model, according to which the specific behaviour of things in the world is the outcome of both the thin powers things have to be subjected to laws, and certain nomic features of the world. The aim of this paper is to show that the most plausible form of the Dualist Model can provide the basis for a novel version of the Powerful Qualities View about properties. To this end it presents ways of developing two aspects of the Dualist Model. It defends the view that nomic relations must be relata-specific in order to play their theoretical role within the Model and provides arguments for the view that natural properties should have the minimum (compatible with the core tenets of the Model) modal strength. (shrink)

The Identity Theory of properties is an increasingly popular metaphysical view that aims to be a middle way between pure powerism and pure categoricalism. This paper’s goal is to highlight three major difficulties that IDT should address in order to be a plausible account of the nature of properties. First, although IDT needs a clear definition of the notion of qualitativity which is both adequate and compatible with the tenets of the theory, all the extant proposals fail to provide such (...) a definition. Second, the suggested definitions of qualitativity are characterised by a metaphysical ‘neutrality’ that threatens to trivialise the important metaphysical debate regarding the question whether properties confer by themselves dispositions on their bearers or need the ‘assistance’ of laws of nature to do that. Finally, none of the extant alternative understandings of the core identity-claim of IDT can adequately meet the objection that the claim in question is unintelligible. (shrink)

The vast majority of metaphysicians agree that powers (in contrast to categorical properties) can exist unmanifested. This paper focuses on the ontological distinction between unmanifested and manifested powers underpinning that fact and has two main aims. First, to determine the proper relata of the distinction and second, to show that an unrestricted version of dispositional monism faces serious difficulties to accommodate it. As far as the first aim is concerned, it is argued that the distinction in question, in order to (...) be free of irrelevant features, must hold between an un- manifested power-instance and the same power-instance being manifested. To the second end, the paper examines two possible candidate distinctions (actual vs. possible, be- ing-in-energeia vs. being-in-capacity). It is argued that the former fails to be a good fit for the role that the distinction under consideration should play in a dispositional monistic context. It is also argued that a specific version of the latter can ground a promising solution to the difficulty discussed in the paper. That solution, however, presupposes the inclusion of aspects of the Aristotelian metaphysical framework for powers to the dispositional monistic context. (shrink)